Downstream Processing
TFF Systems
Bionet is a leading innovator in the field of downstream processing, specializing in Tangential Flow Filtration (TFF) systems. Renowned for their advanced technology and superior performance, Bionet’s TFF systems are designed to enhance the efficiency and effectiveness of bioprocessing workflows.
With ease of integration into existing workflows, making them a preferred choice for biotech and pharmaceutical companies seeking top-notch solutions for their filtration needs.
M1 Benchtop System
M1 benchtop system
The MS tangential flow filtration system is an excellent choice for those seeking a compact solution for the concentration and clarification of biomass and biomolecules derived from microbial fermentation or cell culture processes.
Use a Filter / Cartridge / Hollow Fiber Membrane / Ceramic Filter etc. of your choice !! any make or any brand.
The system uses a Lobular Pump (Not a standard peristaltic pump) assisting in easy scale-up to a Pilot / Production system.
With a high degree of configurability and a range of standardized options, the MS system effectively meets specific downstream processing requirements.
It is particularly suited for applications including cell and lysate clarification, cell harvesting (especially important in the probiotics sector) and the concentration and diafiltration of proteins, peptides, enzymes, recombinant proteins and monoclonal antibodies.
The system can be further categorized into two models:
- M1: Features a 5L glass vessel, ideal for various small-scale applications.
- M1 PLUS: Equipped with a larger 10L glass vessel, providing greater capacity.
System can be controlled Via a smart phone.
Pilot & Industrial TFF Systems
The MS Industrial Tangential Flow Filtration (TFF) system is a highly adaptable solution designed for a wide range of bioprocessing applications, including cell and lysate clarification, cell harvesting and the concentration and diafiltration of proteins, peptides and monoclonal antibodies. With flexible membrane options (hollow fiber, ceramic, spiral, or cassette), the system offers the versatility to meet your specific process needs while ensuring minimal hold-up volume for higher yield and efficiency.
The MS system also provides seamless scalability from benchtop (M1) to industrial scale, maintaining consistent process parameters across all sizes.
MS systems can be equipped with optional cooling and/or heating capabilities via jacketed recirculation vessels and/or dedicated in-line heat exchangers to maintain the desired temperature throughout the process to ensure consistent filtration rate.
Incorporates pumping technology that is specifically adapted to the nature of the product, ensuring gentle and effective processing for shear-sensitive products.
MS systems are configured with the required flow transmitters to guarantee a stable filtration.
Designed with different operating modes depending upon the variable that needs to be controlled (TMP, permeate flow, diafiltration volume etc.) to meet the user's requirement.
The user-friendly design of the MS system allows for easy maintenance and operation.
